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Abstract

In this document, current methods and testing strategies for evaluating the genotoxic effects of chemicals are reviewed. Following an overview of both somatic and germ cell mutagenesis, model organisms and tests in current use are described. Correlations of short term tests with carcinogenicity and germ cell mutagenicity data are assessed and the two main genotoxicity testing strategies, the tier approach and the battery approach, are described. Guidelines currently recommended at international (CEC and OECD), national (United Kingdom, Italy, Japan, Canada, and USA), and industry (European Chemical Industry Ecology and Toxicology Centre) levels are described. It is concluded that, given technological progress, there is scope for improvement of current practices and methodologies. Recommendations for future research and development are given both for in vitro and in vivo genotoxicity tests and for ecosystems and environmental compartments.

Additional information

Authors: CARERE A, Istituto Superiore di Sanità, Roma (IT);MOHN G R, National Institute of Public Health and Environmental Protection, Bilthoven (NL);PARRY J M, University College Swansea (GB);SORS A I, European Commission, DG XII, Bruxelles (BE);NOLAN C V, European Commission, DG XII, Bruxelles (BE)
Bibliographic Reference: EUR 15945 EN (1995) 98pp., FS
Availability: Available from the European Commission, Mr Nolan, DG XII-D-1, 200 rue de la Loi, B-1049 Bruxelles (BE)
ISBN: ISBN 92-827-0081-X
Record Number: 199411375 / Last updated on: 1995-03-21
Category: PUBLICATION
Original language: en
Available languages: en