Community Research and Development Information Service - CORDIS

Abstract

Bone sarcomas may be induced throughout the skeleton (systemic) in mice by relatively low internal alpha-particle doses that are distributed over the whole skeleton. The induction of local (periosteal) bone sarcomas after paratibial deposition of insoluble radiocolloids required much higher doses and, in addition, high energies of emitted particles. Paratibial deposition of alpha-particle-emitting radiocolloids of 227Th and 228Th resulted in formation of both local and systemic bone sarcomas. The latter were most probably induced by the released radium daughters of the thorium isotopes and were distributed about the skeleton. Paratibial injections with beta-particle emitters 144Ce+144Pr (29 kBq per mouse) showed an incidence of local bone sarcomas of more than 80 %. An estimation of the local effective doses led to values of more than 1000 Gy for the beta-particle emitter 144Ce and around 150 Gy for the thorium isotopes. Thus induction of local bone sarcomas required doses considerably greater than those needed for systemic bone sarcomas. The local induction of bone sarcomas has been reported for high energy beta-particles using similar high doses of 144Ce+144Pr in rats and for external 90Sr+90Y irradiation in mice. The processes involved in the induction of local and systemic bone sarcomas by radiation may therefore be quite different.

Additional information

Authors: MÜLLER W A, GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Pathologie, Neuherberg, Oberschleissheim (DE);LUZ A, GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Pathologie, Neuherberg, Oberschleissheim (DE);LINZNER U, GSF-Forschungszentrum für Umwelt und Gesundheit, Institut für Pathologie, Neuherberg, Oberschleissheim (DE);MULLER W A, GSF-Forschungszentrum fur Umwelt und Gesundheit, Institut fur Pathologie, Neuherberg, Oberschleissheim (DE)
Bibliographic Reference: Article: Radiation Research, Vol. 138 (1994) pp. 415-422
Record Number: 199510450 / Last updated on: 1995-04-11
Category: PUBLICATION
Original language: en
Available languages: en