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This paper reviews the need for a concerted international effort in radiation biomarker development in the context of the European Radiation Protection programme. Previous work by this programme on biological dosimetry using dicentric chromosomal aberration induction in blood lymphocytes has been successful for doses in excess of 20 cGy when measurements are made within a few days of exposure. The method using micronuclei induction has been found to be less useful. The technique of chromosome painting allows the use of stable translocation-type aberrations that remain in the lymphocytes, and is being investigated as a possible biomarker to provide a cumulative measure of exposure. The extent to which other factors such as chemical exposure, viral infection or ageing can influence the occurrence of the translocations is a significant problem for study.

Additional information

Authors: SINNAEVE J, European Commission, Bruxelles (BE);CHADWICK K H, European Commission, Bruxelles (BE)
Bibliographic Reference: Article: Biomarkers and Occupational Health : Progress and perspectives (1995) pp. 20-24
Record Number: 199510523 / Last updated on: 1995-04-11
Original language: en
Available languages: en