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  • Generic instability at the agouti locus of the mouse (Mus musculus) : I. Increased reverse mutation frequency to the A(omega) allele in A/a heterozygotes

Abstract

The reverse mutation rate data to the white bellied agouti (A(omega)) allele in heterozygous A/a mice have been compiled and shown to be increased by a factor of at least 350 in comparison to the reverse mutation rate in homozygous a/a mice. Employing tightly linked flanking restriction fragment length polymorphism DNA markers, it has been shown that reversion to A(omega) is associated with crossing over in the vicinity of the agouti locus. The non-agouti (a) allele has been shown recently to contain an 11-kb insert within the first intron of the agouti gene. Together with the present results, these observations suggest possible mechanisms to explain the reversion events.

Additional information

Authors: SANDULACHE R, GSF-Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Oberschleißheim (DE);NEUHÄUSER-KLAUS A, GSF-Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Oberschleißheim (DE);FAVOR J, GSF-Forschungszentrum für Umwelt und Gesundheit, Neuherberg, Oberschleißheim (DE);NEUHAUSER-KLAUS A, GSF-Forschungszentrum fur Umwelt und Gesundheit, Neuherberg, Oberschlei?heim (DE)
Bibliographic Reference: Article: Genetics, Vol. 137 (1994) pp. 1079-1087
Record Number: 199510559 / Last updated on: 1995-04-21
Category: PUBLICATION
Original language: en
Available languages: en