Toxicological mechanisms and the validation of alternative toxicity testing
It is widely accepted that the elucidation of toxicological mechanisms is critical to future progress in the ability to predict more accurately the possible consequences of the exposure of humans, and other species, to chemicals. In recent years, cellular and molecular experimental techniques have undoubtedly strengthened the fundamental science of toxicology. In vitro test systems are ideal for mechanistic studies, which are difficult to undertake in vivo, and for investigations of target organ and target species toxicity. A key challenge now facing toxicologists is the identification of relevant toxicological mechanisms occurring in vivo for which in vitro endpoints can be determined, leading to the development, validation and regulatory acceptance of novel, mechanistically based, in vitro tests. ECVAM's current ideas and priorities in the area of toxicological mechanisms are outlined.
Bibliographic Reference: Paper presented: Toxicological Mechanisms, San Francisco (US), May 15-16, 1995
Availability: Available from (1) as Paper EN 38973 ORA
Record Number: 199510706 / Last updated on: 1995-07-07
Original language: en
Available languages: en