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It was the objective of the clean-up and end-methods testing study to complete the development of an official modular, confirmatory Community method for the detection of beta-agonists in animal feed. Clenbuterol and salbutamol were chosen as representative analytes for the group. Homogeneous pools of primary extracts (blank and contaminated) from three different animal feed matrices were prepared by means of the Community extraction module. The primary extracts were further processed by four laboratories by means of four different clean-up schemes. The final extracts thus obtained were cross-distributed between the same laboratories and measured either by GCMS or HPLC. All clean-up schemes for clenbuterol were found to be compatible with all end-methods. In contrast, for salbutamol, clean-up method D was found not compatible with the end-methods applied by laboratories B and C. The results of this study have clearly demonstrated that the clean-up methods for clenbuterol and for salbutamol applied by laboratory B yielded superior recoveries with an acceptable standard deviation.

Additional information

Authors: LEYSSENS L, Dr L Williams-Instituut VZW, Diepenbeek (NL);MOERMANS R, Rijksstation voor Nematologie, Centrum voor Biometrie, Merelbeke (NL);COURTHEYN D, Rijksontledingslaboratorium, Gentbrugge (NL)
Bibliographic Reference: EUR 16242 EN (1995) 97 pp., FS
Availability: Available from the SMT Programme Office, European Commission, DG XII, 200 rue de la Loi, B-1049 Bruxelles (BE)
ISBN: ISBN 92-827-4120-6
Record Number: 199511041 / Last updated on: 1995-08-18
Original language: en
Available languages: en
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