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  • Use of cell cultures and nuclear and radioanalytical techniques for environmental, occupational and biomedical metal toxicology research at the JRC-Ispra


A review of the JRC-Ispra research activity carried out on cell cultures in combination with nuclear and radioanalytical techniques, as a scientific contribution to the interpretation of metal toxicity, is presented. Applications concern the use of neutron activation analysis and cyclotron-produced radiotracers with high specific radioactivity, which provide information relevant to avoiding experimental false results, for setting uptake-effect relationships, and for understanding the mechanisms of toxicity of specific metal compounds of environmental, occupational and biomedical interest (e.g. Al, As, Cd, Co, Cr, Mn, Pt, Se and V).

Additional information

Authors: SABBIONI E, JRC Ispra (IT);BALLS M, JRC Ispra (IT)
Bibliographic Reference: Paper presented: World Congress on Alternative and Animal Use in the Life Sciences, Baltimore (US), November 14-19, 1993
Availability: Available from (1) as Paper EN 37656 ORA
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