In vitro alternatives in developmental pharmacotoxicologyFunded under: FP3-BIOTECH 1
The aim of this study is to test for unwanted effects of putative toxins in simple and less expensive systems by providing information on parameters such as cell division, fertilisation, differentiation, morphogenesis and metabolism. The results obtained with these systems are compared with those found with traditional methods which employ mammals. The systems under development include: (i) yeast for effects on cell division, genetics and metabolism; (ii) Dictyostelium amoebae for effects on cell division, interaction, differentiation and metabolism; (iii) Drosophila embryos for effects on cell division, genetics and metabolism; (iv) sea urchin eggs for effects on fertilisation, cell division, development and metabolism; (v) cultures of human keratinocytes for effects on cell division, differentiation and morphogenesis.
Bibliographic Reference: Report: EN (1995) 15 pp.
Availability: Available from the BIOTECH Programme Office, European Commission, DG XII, 200 rue de la Loi, B-1049 Bruxelles (BE)
Record Number: 199530209 / Last updated on: 1995-08-10
Original language: en
Available languages: en