Community Research and Development Information Service - CORDIS


The objective of this project was the development of a modular confirmatory Community method for the detection of beta-agonists in animal feed. Clenbuterol and salbutamol were chosen as a representative analytes for the group. Based on these results of preliminary studies, a draft procedure was composed, consisting of three optional methods: gas chromatograph-mass spectrometry (GCMS) method for clenbuterol-type beta-agonists, a high performance liquid chromatography (HPLC) method for clenbuterol-type beta-agonists, and a GCMS-method for salbutamol-type and clenbuterol-type beta-agonists. Results are presented in this report. For clenbuterol the narrow range GCMS method has proved most satisfactory, particularly with respect to practicability and purity of extracts. The number of accepted sets of results with HPLC as the end method was too scarse to draw clear cut quantitative conclusions. The broad range method was found appropriate as a multi-residue method able to simultaneously measure clenbuterol-type and salbutamol-type beta-agonists. To discuss results and practical experience a workshop was organized after termination of the measurements. The final draft procedure was prepared, taking into account the agreements made during the final meeting of the participants.

Additional information

Authors: LEYSSENS L, Dr I Willems-Instituut, Diepenbeek (BE);BOENKE A A, CEC Bruxelles (BE);COURTHEYN D, Rijksontledingslaboratorium, Gentbrugge (BE)
Bibliographic Reference: EUR 16674 EN (1995) 54pp., FS, free of charge
Availability: Available from the European Commission, Dr A Bönke, DG XII-C-5, 200 rue de la Loi, B-1049 Bruxelles (BE)
ISBN: ISBN 92-827-5327-1
Record Number: 199610227 / Last updated on: 1996-03-29
Original language: en
Available languages: en