Recovery of Bi-213 from an Ac-225 Cow: Application to the Radiolabelling of Antibodies with Bi-213
In this paper, we report an investigation of the radiochemistry and labelling chemistries of Bi-213. The recovery of Bi-213 was optimal when a mixture of 0.1M HCl and HI were used as eluant, and the Bi-213 was found to be radiochemically pure. The Ac-225 cow yielded Bi-213 which gave a high specific activity mAb M195-CHXA DTPA product, which was limited by the amount of Ac-225 currently available. Preliminary cell-binding studies with In-111 show that this nuclide is taken up rapidly by cells. By comparison, cell-killing studies with Bi-212 show that Bi-212 labelled mAb M195-CHXA DTPA is most effected at high specific activity.
Bibliographic Reference: Article: Chemists' Views of Imaging Centers (1995) pp. 315-322
Record Number: 199610365 / Last updated on: 1996-04-15
Original language: en
Available languages: en