The EC/HO International Validation Study on Alternatives to the Draize Eye Irritation Test
This is the final report of the Management Team for a European Commission/British Home Office (EC/HO) validation study on alternatives to the Draize eye irritation test. The principal goal of the study was to establish whether one or more of 9 non-animal tests could be used to replace the Draize test for all severely irritating materials (or those belonging to specific classes) or the animal test completely for chemical with or without regard to chemical class. Sixty chemicals were independently selected, coded and supplied, then the data obtained in 37 laboratories were analysed independently. With the possible exception of predicting the irritancy of surfactants, none of the 9 tests met any of the 4 performance targets. Possible reasons for this outcome are discussed.
Bibliographic Reference: Article: Toxicology in Vitro, Vol. 9 (1995) No. 6, pp. 871-929
Record Number: 199610368 / Last updated on: 1996-04-15
Original language: en
Available languages: en