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This chapter is based primarily on the conclusions and recommendations of the CAAT/ERGATT workshop on validation, the ERGATT workshop on regulatory acceptance, and the ECVAM/ERGATT workshop on practical aspects of validation. The undoubted potential of in vitro methods, not only as a basis for a more modern, more scientifically based toxicology, but also as a basis for the more scientific application of toxicity tests, represents a great challenge to in vitro toxicologists, whose contribution to the development, validation and assessment of new methods and procedures will be crucial. It is very important that regulatory incorporation should be a permissive process, rather than a restrictive one. In addition, regulatory guidelines must be interpreted with greater flexibility than hitherto. Any well-designed and scientifically defensible study incorporating any properly validated and independently recommended test procedures should be acceptable.

Additional information

Authors: BALLS M, JRC Ispra (IT);FENTEM J H, JRC Ispra (IT);CLOTHIER R H, University of Nottingham, Department of Human Morphology (GB);NADOLNEY C H, Environmental Protection Agency, Office of Pesticides and Toxic Substances, Washington (US)
Bibliographic Reference: Article: Handbook on In Vitro Toxicology (1996)
Record Number: 199610475 / Last updated on: 1996-05-20
Original language: en
Available languages: en
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