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The past decade has seen considerable research effort directed toward establishing the potential usefulness of in vitro cytotoxicity tests. However, many of the studies undertaken have been somewhat uncritical, in that sweeping generalizations about the full spectrum of test materials have been made on the basis of rather limited investigations with chemicals which can be studied by using particular test endpoints and endpoint measurements with relative ease. Nevertheless, it would appear that, despite all the expected complications likely to be caused by biokinetic factors in vivo, a very good correlation exists between the in vitro ID50 and the in vivo LD50 values for some chemicals, but not for others. Therefore, given a series of truly new chemical entities, one would not know whether predictions based on basal cytotoxicity data alone would or would not be useful indicators of their likely in vivo effects. Suggestions for approaches which could be employed to overcome this difficulty are given.

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Authors: FENTEM J H, JRC Ispra (IT);BALLS M, JRC Ispra (IT);CLOTHIER R H, University of Nottingham, Department of Human Morphology (GB);GARLE M J, University of Nottingham, Department of Human Morphology (GB)
Bibliographic Reference: Article: Handbook on In Vitro Toxicology (1996)
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