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In this chapter, we consider both the general role and varied application of in vitro methods in pharmaceutical research, particularly in drug discovery, and then comment more briefly on reduction and refinement alternatives. The extent and nature of the use of in vitro methods (when, why and how such methods are used, and their role in complementing, as well as in providing replacement alternatives for, in vivo methods), and progress in their application in the development and testing of pharmaceuticals in recent years, and the problems encountered, are discussed.

Additional information

Authors: STRAUGHAN D W, FRAME, Nottingham (GB);FENTEM J H, JRC Ispra (IT);BALLS H, JRC Ispra (IT)
Bibliographic Reference: Article: In Vitro Methods in Pharmaceutical Research (1996)
Record Number: 199610478 / Last updated on: 1996-05-20
Original language: en
Available languages: en