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Lymphocyte subpopulations were determined in 28 traffic policemen and in 14 male control subjects of a town in Central Italy. One half of each group was composed of smokers. The total number of lymphocytes and lymphocyte subpopulations, determined by flow cytometric analysis, were not significantly altered in the traffic policemen who were smokers. However, in the nonsmoking traffic policemen, both number and percentage of CD8+ lymphocytes were significantly augmented by about 25%, while the percentage of CD4+ lymphocytes and the CD4+ to CD8+ ratio were significantly reduced by 22% and 35%, respectively. Urinary lead (a toxic marker produced by vehicular traffic) was higher in the traffic policeman than in the control group; serum copper was slightly augmented in the traffic policeman and in all the smokers; serum zinc was not modified. Highly significant correlations were found between urinary lead and CD16+ cells (mainly natural killer lymphocytes) and between serum copper and HLA-DR+ cells (B and activated T lymphocytes).

Additional information

Authors: CERVONE M ET AL, Altri Hospital, Immunology and Allergology Division, Pescara (IT);BOSCOLO P ET AL, University G D'Annunzio, Centre of Occupational Medicine and Department of Quantitative Method, Chieti and Pescara (IT);SABBIONI E, JRC Ispra (IT);GIULIANO G, University of Florence, Institute of Occupational Medicine (IT)
Bibliographic Reference: Article: International Journal of Immunopathology and Pharmacology, Vol. 8 (1995), No. 1, pp. 15-22
Record Number: 199610540 / Last updated on: 1996-05-27
Original language: en
Available languages: en