The Integrated Use of Alternative Approaches for Predicting Toxic Hazard
Ways in which quantitative structure-activity relationships (QSAR) might be used in the design, evaluation and validation of in vitro tests, and in the section of appropriate test chemicals for validation studies, are described. Reference is made to the following: availability of high quality data; integration of QSAR and in vitro methods; and methodology (physiologically based pharmacokinetic (PBPK) modelling, statistical methods), validation and selection of test chemicals.
Bibliographic Reference: Article: Alternatives to Laboratory Animals, Vol. 23 (1995), pp. 410-429
Record Number: 199610547 / Last updated on: 1996-05-27
Original language: en
Available languages: en