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Ways in which quantitative structure-activity relationships (QSAR) might be used in the design, evaluation and validation of in vitro tests, and in the section of appropriate test chemicals for validation studies, are described. Reference is made to the following: availability of high quality data; integration of QSAR and in vitro methods; and methodology (physiologically based pharmacokinetic (PBPK) modelling, statistical methods), validation and selection of test chemicals.

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Authors: BARRATT M D ET AL, Unilever Research, Environmental Safety Laboratory, Bedford (GB);CASTELL J V, Hospital Universitario La Fe, Unidad de Hepatologia Experimental, Valencia (ES);COMBES R D, FRAME, Nottingham (GB);DEARDEN J C, John Moores University, School of Pharmacy, Liverpool (GB);FENTEM J H, JRC Ispra (IT);GERNER I, Bundesinstitut für Gesundheitlichen Verbraucherschutz und Veterinärmedizin, Berlin (DE);GUILIANI A, Istituto di Ricera sulla Senescenza, Pomezia (IT);GRAY T J B, Alnwick Research Centre, Sanofi Research Division (GB);LIVINGSTONE D J, ChemQuest, Steeple Morden (GB);MCLEAN PROVAN W, ZENECA, Central Toxicology Laboratory, Macclesfield (GB);RUTTEN F A J J L, TNO Nutrition and Food Research Institute, Division of Toxicology, Zeist (NL);VERHAAR H J M, Utrecht University, Research Institute of Toxicology (NL);ZBINDEN P, SIAT, Basel (CH)
Bibliographic Reference: Article: Alternatives to Laboratory Animals, Vol. 23 (1995), pp. 410-429
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