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Validation activities in Europe are described, with reference to both past and ongoing studies. These test methods have included the use of cytotoxicity data to predict the acute toxicities of chemicals, and the use of in vitro methods to predict eye irritancy, developmental toxicity, hepatotoxicity and neurotoxicity. Recently, the European Research Group for Alternatives in Toxicity Testing (ERGATT) established a multicentre research project, in which tests or test batteries were selected within eight areas: basal cytotoxicity, irritancy, developmental toxicity, hepatotoxicity, nephrotoxicity, immunotoxicity, neurotoxicity and biokinetics The aim of the programme is to integrate knowledge of the different areas, as much as possible on the basis of knowledge of mechanisms of toxic action, into an overall assessment of the compound's toxicological hazards.

Additional information

Authors: BLAAUBOER B J, Utrecht University, Research Institute of Toxicology (NL);BALLS M, JRC Ispra (IT)
Bibliographic Reference: Article: The World Congress on Alternatives and Animal Use in the Life Sciences : Education, Research, Testing (1996), pp. 411-414
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