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Electrospray Ionization (ESI) has become a routine technique of enormous importance for analysis of biomolecules like proteins and peptides. Application of ESI to biological problems can benefit from the mass resolution and mass range of double focusing magnetic sector mass spectrometers because of their high resolving power and sensitivity. One particularity of electrospray (ES) sectors is the complexity of the interface design due to high potentials of sector instruments. Detection limits are related to the mass spectrometer transmisison and the detector sensitivity. In the case of sector instruments with array detection, problems of dispersion can be partially removed. Nevertheless high resolution work on magnetic sector instruments requires very intense and stable ion currents, often not easily achievable when sample amounts are limited. Several improvements have been suggested, by increasing the efficiency of ion transmission from the source to the analyser region, or by miniaturizing the spray process.

Additional information

Authors: SARU F, JRC Ispra (IT);MONTANARELLA L, Ecole Normale Supérieure, Département Chimie, Paris (FR)
Bibliographic Reference: Article: Reviews in Analytical Chemistry (1996)
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