Community Research and Development Information Service - CORDIS

Abstract

The role of the European Centre for the Validation of Alternative Methods (ECVAM) in the practical validation of replacement alternative methods for use in regulatory testing has been reviewed and incudes an outline of the criteria which have been used in determining ECVAMs priorities. Some of the difficulties which have arisen in validation studies were discussed, and solutions to these are proposed, with particular emphasis on ensuring that methods are sufficiently well developed to enter the validation process, and on the ECVAM prevalidation scheme for encouraging protocol optimization and the prior assessment of interlaboratory transferability. Comments were made on problems encountered in selecting test materials backed by adequate in vivo data and in undertaking appropriate in vivo/in vitro comparison. Finally, reference was made to ECVAM's activities related to dermal toxicity testing.

Additional information

Authors: BALLS M, JRC Ispra (IT);FENTEM J H, JRC Ispra (IT)
Bibliographic Reference: Paper presented: 4th Annual New Technologies Workshop, Bethesda (US), September 14-15, 1995
Availability: Available from (1) as Paper EN 39634 ORA
Record Number: 199610612 / Last updated on: 1996-05-27
Category: PUBLICATION
Original language: en
Available languages: en