Community Research and Development Information Service - CORDIS

Abstract

In vitro systems offer a number of advantages for metabolism and safety studies in drug discovery and development. They are ideal for mechanistic studies, can be used to overcome problems created by species differences, and offer an escape from the ethical dilemmas inherent in using laboratory animals. These issues are discussed in the context of the use of in vitro methods as screens for pharmacological activity and for potential toxicity, in studies on biotransformation, and the determination of biokinetic parameters.

Additional information

Authors: BALLS M, JRC Ispra (IT);FENTEM J H, JRC Ispra (IT);STRAUGHAN D W, FRAME Nottingham (GB)
Bibliographic Reference: Paper presented: Euro Residue III, Veldhoven (NL), May 6-8, 1996
Availability: Available from (1) as Paper EN 39695 ORA
Record Number: 199610627 / Last updated on: 1996-05-27
Category: PUBLICATION
Original language: en
Available languages: en