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  • Structure-activity relationship in the induction of chromosomal aberrations and spindle disturbances in Chinese hamster epithelial liver cells by regioisomeric phenanthrene quinones

Abstract

Four regioisomeric phenanthrene (PH) quinones (Q) were investigated for their abilities to induce chromosomal damage and spindle disturbances. PH 1,4-Q and PH 1,2-Q induced structural as well as numerical chromosomal aberrations, whereas the isomers PH 9,10-Q and PH 3,4-Q showed no significant effects in this regard. However, all four compounds enhanced the frequency of c-mitoses.

Additional information

Authors: TURCHI G, JRC Ispra (IT);GLATT H R, German Institute of Human Nutrition, Potsdam (DE);SEIDEL A, University of Mainz, Institute of Toxicology (DE);PULITI A, Universita di Pisa, Dipartimento di Scienze dell'Ambiente e del Territorio (IT);SBRANA I, Universita di Pisa, Dipartimento di Scienze dell'Ambiente e del Territorio (IT)
Bibliographic Reference: Article: Cell Biology and Toxicology (1996)
Record Number: 199610873 / Last updated on: 1996-09-16
Category: PUBLICATION
Original language: en
Available languages: en
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