Community Research and Development Information Service - CORDIS

Abstract

This paper describes in vitro cytotoxicity experiments with (213)Bi and (225)Ac immunoconjugates on the human epidermoid tumour cell line A431 using a blood group A-reactive murine immunoglobulin G (IgG) (2D11) as the specific antibody and MOPC 21 as the control antibody. With both radionuclides, specific cell-killing was achieved. The observed cytotoxicity of (213)Bi (T(½) = 47 min) indicates that this radionuclide is a useful alternative for the alpha-emitter (212)Bi in the treatment of blood-borne malignancies. (225) Ac-immunoconjugates (T(½) of (225)Ac is 10 days) may be applicable for the treatment of solid tumours, since the daughter radionuclides of (225)Ac contribute to the cytotoxic efficacy by a field effect (ie toxicity in an area distal from the antibody-binding site). The lack of an adquate chelator for (225)Ac is a major drawback.

Additional information

Authors: KASPERSEN F M, NV Organon, Oss (NL);BOS E, NV Organon, Oss (NL);DOORNMALEN A V, NV Organon, Oss (NL);GEERLINGS M W, Alphamedical Holding BV, Amsterdam (NL:);APOSTOLIDIS C, JRC Karlsruhe (DE);MOLINET R, JRC Karlsruhe (DE)
Bibliographic Reference: Article: Nuclear Medicine Communications, Vol. 16 (1995) pp. 468-476
Record Number: 199611067 / Last updated on: 1996-09-30
Category: PUBLICATION
Original language: en
Available languages: en