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A procedure is described to derive inductively coupled plasma-mass spectrometry (ICP-MS) mass bias from an instrument's response function. Using well known equations an interesting relationship between mass bias and response function is made visible, which can provide some additional information for the detection of isobaric interferences in isotope abundance ratio measurements. The ion currents of different isotopes are measured as they result from a multi-element test solution containing 10 ng/g of Be, Mg, Co, In, La, Pb, Bi and U. The molar response is calculated after normalizing for differences in isotope abundances and element ionization efficiencies. From this data, the mass bias curve can be obtained which can be used as a diagnostic tool to evaluate observed isotope abundance ratios. The approach has been applied to a quadrupole and a high resolution ICP-MS instrument. Mass bias curves for both instruments were fairly similar and agreed with experimental values.

Additional information

Authors: HELD A, JRC Ispra (IT);TAYLOR P D P, JRC Ispra (IT)
Bibliographic Reference: Article: Journal of Analytical Atomic Spectrometry (1997)
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