Application of microanalytical techniques in in vitro toxicity testing
In in vitro pharmacotoxicology, techniques which permit detection at very low levels are highly desirable. By using microplate techniques (with fewer cells), it is possible to measure a number of parameters such as NRU and MTT, EROD and PROD activities, and in parallel the metabolism of compounds of interest by detection and quantitation with high performance liquid chromatography (HPLC), electrochemical detection, mass spectrometry, etc. Such studies have the advantage of being a multidisciplinary approach to evaluate biological effects, as well as saving biological materials (cells, animals) and chemicals.
Bibliographic Reference: Paper presented: 3rd PharmAnalysis Europe Conference, Chester (GB), October 21-22, 1996
Availability: Available from (1) as Paper EN 39863 ORA
Record Number: 199710197 / Last updated on: 1997-04-01
Original language: en
Available languages: en