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Assessment of the relevance and reliability of alternative toxicological methods requires the application of biostatistical methods. This report contains the recommendations of the ECVAM Task Force on Biostatistics for the appropriate use of biometrical methods, and for closer collaboration between biostatisticians and experimental toxicologists in the development and validation of alternative methods. The main objectives of these recommendations are to improve the compatibility of the results obtained from different studies, and to prevent the misinterpretation of statistical analyses.

Additional information

Authors: HOLZHUTTER H-G, Humboldt-Universität zu Berlin, Institut für Biochemie (DE);ARCHER G, JRC Ispra (IT);SALTELLI A, JRC Ispra (IT);DAMI N, L'Oréal, Aulnay-sous-Bois (FR);LOVELL D P, BIBRA International, Carshalton (GB);SJOSTROM M, Umeå University, Department of Organic Chemistry (SE)
Bibliographic Reference: Article: ATLA, Vol. 24 (1996) pp. 511-530
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