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Abstract

Stability testing and monitoring are of the highest importance for the certification of reference materials. However, in general, the results of these measurements are assessed quite qualitatively, and no effort is made to quantify the duration of validity of the certificate. The new International Standardisation Organisation (ISO) Guide 31: Contents of certificates, certification reports and labels of reference materials, will most probably contain the explicite obligation to mention an expiry date for all certified reference materials (CRM) where instability has been demonstrated or is considered possible. Therefore a method is proposed for quantifying the expected shelf-life on the basis of linear regression and determination of the intersection of the lower confidence limit of the certified value with the 95% lower confidence bound of the mean degradation curve.

Additional information

Authors: PAUWELS J, JRC Geel (BE);LAMBERTY A, JRC Geel (BE);SCHIMMEL H, JRC Geel (BE)
Bibliographic Reference: Article: Fresenius Journal of Analytical Chemistry (1997)
Record Number: 199711532 / Last updated on: 1997-12-09
Category: PUBLICATION
Original language: en
Available languages: en