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Abstract

There are several ongoing medical trials to use Bi-213 conjugated to monoclonal antibodies to kill tumour-cells of various cancer types. The institute is supplying Ac-225 generators for the test and is itself engaged in in-vitro cytotoxicity tests.
The present supply of Ac- 225 stems from Th-229 decay obtained from aged U-233. From possible alternative the reaction Ra-226 (p,2n) Ac-225 is presently favoured. The fabrication of Ac-225 for Bi-213 generators will be described.

Additional information

Authors: KOCH L, ITU Karlsruhe, Karlsruhe (DE);APOSTOLIDIS C, ITU Karlsruhe, Karlsruhe (DE);JANSSENS W, ITU Karlsruhe, Karlsruhe (DE);MOLINET R, ITU Karlsruhe, Karlsruhe (DE);VAN GEEL J, ITU Karlsruhe, Karlsruhe (DE)
Bibliographic Reference: Paper presented: 13th Radiochemical Conference, Prague (CZ), April 19-24th, 1998
Availability: Available from DG XIII as Paper EN 41940 ORA
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