Community Research and Development Information Service - CORDIS


COST is the acronym for the organization for European Co-operation in the field of Scientific and Technical Research. COST serves as a framework for co-operative research throughout Europe and Scandinavia, not just the European Union, on topics of mutual benefit. There are currently 25 member states in COST, which serves a s a catalyst for research by supporting concentration within its actions, in which participation is a la carte.
In 1985, it was proposed to the Senior Officials of COST that there was an urgent need to provide some means to evaluate the clinical significance of the rapid advances being made in the field of interindividual variability in drug metabolism, and particularly in pharmacogenetics. As a consequence, COST Action B1, entitled Criteria for the Choice and Definition of Healthy Volunteers and Patients for Phase I and Phase II Studies in Drug Development, was launched in early 1986. It was the first biomedical action within COST. The first phase of the Action ran for 5 years, after which it was approved for a second phase, of 4 years, starting in early 1991. This was entitled The Role of Metabolic and Kinetic Studies in Drug Research and Development. Phase 2 was completed at the beginning of 1995, after which a third and final phase was approved, with the title Predicting and Managing Variability in the Kinetics of Drugs During their Discovery, Development and use.COST Action B1 finished in February of 1998.
COST Action B1 has played a role in a number of research areas of relevance to drug development and use, initially in pharmacokinetics but latterly also in pharmacodynamics. These have included pharmacogenetic and non-pharmacogenetic sources of variability, pharmacokinetic/pharmacodynamid modelling, population approaches to assessing variability and assessing drug metabolism in man. One of the ways in which a COST Action can achieve its goals as a catalyst and disseminator of ideas is to hold international conferences on topical issues

Additional information

Bibliographic Reference: EUR 18569 EN (1998)
ISBN: ISBN 92-828-5114-1
Record Number: 199910456 / Last updated on: 1999-03-19
Original language: en
Available languages: en
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