Community Research and Development Information Service - CORDIS

Abstract

Specific genes that are subject to discrete, high frequency mutations that independently affect the expression and the size of the protein products and mechanisms involving DNA rearrangements as a means of high-frequency antigenic variation have been reported for several mycoplasma pathogens. The widespread distribution of multigene families encoding variable components reflects their importance, though very little is known about their specific function. These systems may enable the pathogen to adapt to diverse host niches and research has indicated they can be used by mycoplasmas to escape the host immune response. While antigenic variation can severely complicate the final outcome of routine identification of mycoplasma, variable surface proteins of mycoplasmas may offer valuable tools for epidemiological studies and the design of new serodiagnostic assays.

Additional information

Authors: STIPKOVITS L, Veterinary medical Research Institute, Budapest (HU);ROSENGARTEN R, University of Veterinary Medicine, Vienna (AT);FREY J, Institute for Veterinary Bacteriology, University of Berne (CH)
Bibliographic Reference: EUR 18756 EN (1999) 191pp.
Availability: COST PUBLICATIONS ARE TO BE ORDERED THROUGH OOPEC SALES POINTS AT http://eur-op.eu/general/fr/index.htm
ISBN: ISBN 92-828-5222-9
Record Number: 199910584 / Last updated on: 1999-04-01
Category: PUBLICATION
Original language: en
Available languages: en