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In the past decade 'in vitro' tests have been developed that represent a range of anatomic structure from perfused whole organs to subcellular fractions. To assess the use of 'in vitro' tests for toxicity testing, we describe and evaluate the current status of organotypic cultures for the major target cultures for the major target organs of toxic agents. This includes liver, kidney, neural tissue, the hematopoietic system, the immune system, reproductive organs, and the endocrine system. The second part of this report reviews the application of 'in vitro' culture systems to organ specific toxicity and evaluates the a[[lication of these systems both in industry for safety assessment and in government for regulatory purposes.

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Authors: SPIELMAN H, ZEBET, Berlin (DE);BOCHOV N P, Russian Academy of Medical Sciences (RU);COSTA L, University of Washington (US);GRIBALDO L, IHCP, MVMC Unit, ECVAM, Inserm, Rennes (FR);GULLOUZO A, NIEHS, Carolina (US);HEIDEL JJ, University of Pittsburg (US);KAROL M, University of Wayne (US);PARCHMENT R, University of Innsbruck (AT);PFALLER W,
Bibliographic Reference: Article: Environmental health Perspectives, 106 (1998)2, 427-439
Record Number: 199910691 / Last updated on: 1999-05-08
Original language: en
Available languages: en