Oncogene Transgenic Mice: An useful model to study 'in vivo' the relationships between gangliosides and oncogenes
Several studies have demonstrated that transfer of oncogenes in cultured cells reproducibly induces transmissible alterations in their ganglioside profile; the transfection of the same oncogene into different cell lines and the different localization of the oncogene product result in a different ganglioside expression. In the present study the modifications of the ganglioside pattern in mammary carcinomas induced in transgenic mice by the activated form of the rat neu oncogene have been investigated. Whereas control mammary tissues contain quite exclusively GM(3), al neoplastic samples show a substantial decrease of this ganglioside, an accumulation in variable amount of GM(3)-derived species and the appearance of a new, not yet identified, sialic acid containing molecules. Interestingly, three out of ten tumors analyzed, even if histologically comparable to the others but with a larger dimension, show a significant difference as regard to the GM(1), GD(3) and GD(1a) content. Our data suggests that an activated oncogene may induce also in 'vivo' a specific and transmissable alteration in the ganglioside pattern, but this distribution could be susceptible to further modifications during the tumor progression.
Bibliographic Reference: Article: Cancer Biochemistry and Biophysics, 16 (1998), 229-242
Record Number: 199910698 / Last updated on: 1999-05-08
Original language: en
Available languages: en