Oncogene transgenic Mice: An useful model to study 'in vivo' the relationships between gangliosides and oncogenes
Several studies have demonstrated that transfer of oncogenes in cultured cells reproducibly induces transmissable alterations in their ganglioside expression. In the present study the modifications of the ganglioside pattern in mammary carcinomas induced in transgenic mice by the activated form of the rat neu oncogene have been investigated. Whereas control mammary tissues contain quite exclusively GM(3), all neoplastic samples show a substantial decrease of this ganglioside, an accumulation in variable amount of GM(3)-derived species and the appearance of new, not yet identified, sialic acid containing molecules. Interestingly, 3 out of 10 tumors analyzed, even if histologically comparable to the others but with a larger dimension, show a significative difference as regard to the GM(1), GD(3) and GD(1a) content. Our data suggest that an activated oncogene may induce also 'in vivo' a specific and transmissible alteration in the ganglioside pattern, but this distribution could be susceptible to further modifications during the tumor progression.
Bibliographic Reference: Article: Cancer Biochemistry and Biophysics, 16 (1998), 229-242
Record Number: 199910710 / Last updated on: 1999-05-14
Original language: en
Available languages: en