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  • Comparison of in vitro drug sensitivity of human granulocyte macrophage progenitors from two different origins: umbilical cord blood and bone marrow


Predictive in vitro hematotoxicity assays employing human cells will provide estimation of tolerable level and aid considerably the development of magnets with greater therapeutic activity and less toxicity. Human hematopoietic cells can be derived from three sources: human bone marrow by sternal or femoral aspiration, mobilized peripheral blood or umbilical cord blood samples collected from placentas after deliveries. Because of the difficulties to have a continuous supply of bone marrow cells from normal human donors and the related ethical problems, we performed a study to compare the sensitivity of human bone marrow cells and human cord blood cells to chemicals in order to confirm if h-CBC can readily replace bone marrow cells in checking the sensitivity of GM-CFU progenitors to drugs as preliminarily reported in literature.

Additional information

Authors: PESSINA A, Istituto Microbiologia Medica Milano, Milano (IT);GRIBALDO L, ECVA-IHCP, Ispra (IT);CASATI S, ECVA-IHCP, Ispra (IT);CASTOLDI A, Centro Ricerche Salvatore maugeri (IT)
Bibliographic Reference: Article: Experimental Hematology (1999)
Record Number: 199911131 / Last updated on: 1999-08-13
Original language: en
Available languages: en
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