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A mechanism can be defined as an explanation of an observed phenomenon that explains the processes underlying the phenomenon in terms of events at lower levels of organization. The development of high-fidelity, high discrimination tests with a sound mechanistic basis will also require greater appreciation of the interdependance of all the components of test systems and the development of new alternative testing strategies that can provide the specific knowledge needed for making relevant and reliable predictions about the potential effects of chemicals and products on human beings. The optimal use of this new knowledge will require fundamental changes to current practises in ris assessment

Additional information

Authors: BALLS M, EI, JRC-Ispra (IT)
Bibliographic Reference: Article: Environmental Health Perspectives, 206 (1998), 453-457
Record Number: 199911145 / Last updated on: 1999-08-13
Original language: en
Available languages: en