Metallotheinein Isoform Separation by MECC using SDS Micelles
Metallothioneins constitute a class of low molecular mass proteins, characterized by their resistance to thermocoagulation and acid precipitation, by a high cysteine content and lack of aromatic amino acids. MT is a protein induced by various stimuli such as metals, stress and some drugs. MT has the ability to bind metals such as zinc, cadmium, copper and mercury. The MT isoforms are a product of genetic polymorphism characteristic of MT genes in animals and humans. Most MTs have two major isoforms. Furthermore, many animal species generate various sub-isoforms of MT-1 and MT-2, therefore displaying significant microheterogeneity.
Bibliographic Reference: Paper presented: 3rd Miniaturization in Liquid Chromatography versus Capillary Electrophoresis Conference, Gent (BE), 25-28th May (1999)
Availability: Available from Public Relations and Publications Unit, Ispra (IT)
Record Number: 199911242 / Last updated on: 1999-08-27
Original language: en
Available languages: en