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Abstract

Four rapid tests for the diagnosis of BSE have been evaluated with blinded samples. All four tests evaluated are based on immunoassay. The evaluation of the tests was carried out under the supervision of staff of the European Commission not being aware of the identity of the samples to allow an objective assessment. The findings on the sensitivity, specificity and detection limits are summarized. Three tests gave a sensitivity and specificity of 100%. These three tests have an excellent potential for detecting and confirming clinical BSE cases. The ability of the tests to detect small concentrations of PrPSc prions gives grounds for optimism that they could detect infected animals before the development of clinical signs.

Additional information

Authors: MOYNAUGH J, DG XXIV (BE);SCHIMMEL H, IRMM, JRC-Geel (BE)
Bibliographic Reference: Article: Nature 400 (1999)
Record Number: 199911390 / Last updated on: 1999-09-17
Category: PUBLICATION
Original language: en
Available languages: en