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The objectives of COST 918 was to describe from the molecular to the physiological levels, the integrated metabolic system that defines mammalian body weight as well as how body weight and body weight controls are affected by fine regulation of this integrated system. From a basic point of view the findings of this Action will allow for a better understanding of the complex and integrated mechanisms that regulate energy expenditure, food intake and the level of fat stores as well as the identification of new functions of food components meaningful to energy balance. The potential of exploiting such knowledge includes the treatment of obesity, other body weight disorders and the improvement of food production. It seems viable therefore that the results of the Action will contribute towards the design, synthesis and testing of new foods as well as optimising the industrial processing methods for their manufacture.The overall scientific objectives of the Action are broken down as follows:

-In humans, the assessment of the physiological significance of facultative thermogenesis and of the importance of genetic variants of obesity-related genes.

-Identification and molecular characterization of genes selectively expressed in brown and/or white adipose tissues and the protein products.

-Study of the regulation of the proliferation/differentiation program of brown and white adipocytes and their functional status.

-Control of energy efficient regulation in intact animals and prospecting of alternative mechanisms regulating energy balance.

-Design, synthesis and testing of new foods, drugs and/or treatments capable of enhancing thermogenesis without undesirable side-effects, including clinical studies and multi-centre trials on novel foods, on the basis of the results obtained in the above listed areas.

Additional information

Authors: DG-Research,
Bibliographic Reference: EUR 19246 EN (2000) 43pp, ECU free
Availability: Available form OOPEC L-2985
ISBN: ISBN 92-828-9039-2
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