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Abstract

Homogeneity and stability are two crucial characteristics of any CRM. Utmost care must be taken during preparation to create materials as homogeneous and stable as possible. Degradation can generally be minimized by reducing the water activity of the material to a level between 0. 1 5 and 0.35. However, careful preparation by itself is not enough. Positive demonstration of homogeneity and stability is required from the perspective of implementing uncertainty calculus according to the GUM. In many cases, homogeneity and stability studies fail to give sufficient quantitative information on homogeneity and stability, mainly because of a lack of measurement repeatability and insufficient number of replicates. In this work, some solutions to these problems and their implications are presented.

Additional information

Authors: VAN DER VEEN A, Nederlands Meetinstituut (Nmi),Delft, NL;LINSINGER T, JRC, IRMM, RM;PAUWELS J, JRC, IRMM, RM;SCHIMMEL H, JRC, IRMM, RM;LAMBERTY A, JRC, IRMM, RM
Bibliographic Reference: Paper presented: Analytica Conference 2000, München (DE), 11-14 April, 2000
Availability: EC Joint Research Centre IRMM
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