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Abstract

This species survives anoxia by downregulating protein synthesis (i.e. a major consumer of cellular ATP) in the liver and muscle. yet retains synthesis in the brain. This presentation shows how pre-translational events contribute to this survival strategy. In the brain a reduction in RNA synthesis prevents neuron apoptosis whilst an increase in liver RNA synthesis assists in ribosomal repair as well the production of specific RNA species. These changes are achieved by maintaining a fixed energetic cost of RNA synthesis: this being achieved by tissue specific exploitation of the differential energy costs of intracellular nucleotide synthesis and erogenous salvage.

Additional information

Authors: SMITH R W, JRC Ispra, Env. Inst., Enc. Assessment;HOULIHAN D H, UK, Aberdeen, Un. Of Aberdeen, Dept. Zool;NILSSON G E, Norway, Oslo, Un. Of Oslo,. Div. Gen. Ph;ALEXANDRE J, FRANCE, Cell Physiology, Campus Beaulieu
Bibliographic Reference: Paper presented: International Congress on the Biology of Fish, Aberdeen (UK), 23-27 July, 2000
Availability: EC Joint Research Centre PR and Publications unit, Environment Institute, TP 460, 21 020 Ispra (Varese), IT
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