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Due to limitations in existing microdosimetry models, a new model called "MICOR" has been written to analyze the spatial distribution of microscopic energy deposition for Boron Neutron Capture Therapy. In this model the reactions independent of the incident neutron energy, like the boron and the nitrogen reaction can be considered as well as the reactions which depend clearly on the neutron energy like the proton recoil reaction. The model "MICOR" has been extended to be able to determine biological effects of BNCT, which is lacking in the existing models. This article is written in two parts. This part describes the determination of the microscopic quantities. Part II deals with the conversion of the microscopic quantities in biological effects.

The model is used to analyze a radiobiological experiment performed at the HB11 facility in the HFR in Petten. This analysis shows the value of the model in analyzing the dose depositions on a cellular scale, and the importance of the extension to the energy deposition of the proton recoil. .

Additional information

Authors: VROEGINDEWEIJ C, JRC, HFR Unit, Petten (NL);FLOYD W, INEEL, Idaho Falls, Idaho (US);STECHER-RASMUSSEN F, NRG, Petten (NL);HUISKAMP R, NRG, Petten (NL)
Bibliographic Reference: Article: Radiation Research
Availability: Radiation Research (Journal)
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