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A model has been developed to obtain a better understanding of the effects of Boron Neutron Capture Therapy (BNCT) on a cellular scale. This model, the microdosimetry model MICOR, has been developed to include all reactions important for BNCT. To make this model more powerful in the translation from energy deposition to biological effect, the developed model is capable of calculating the effectiveness function. Based on this function, the model can calculate surviving fractions, RBE values and boron concentration distributions. MICOR has been used to analyze an extensive set of biological experiments performed at the HB11 beam in Petten. For V79 cells the effectiveness function is determined, and used to generate surviving fractions. These fractions are compared with measured surviving fractions which has lead to a very good agreement between the measured and calculated surviving fractions (within the uncertainties of the measurements).

Additional information

Authors: VROEGINDEWEIJ C, JRC, HFR Unit, Petten (NL);FLOYD W, INEEL, Idaho Falls, Idaho (US);STECHER-RASMUSSEN F, NRG, Petten (NL);HUISKAMP R, NRG, Petten (NL)
Bibliographic Reference: Article: Radiation Research
Availability: Radiation Research (Journal)
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