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Abstract

The Institute for Reference Materials and Measurements (IRMM) and the International Federation for Clinical Chemistry and Laboratory Medicine (IFCC) have certified a reference material (CRM) under the name and number IRMM/IFCC-454. This report describes the certification of the catalytic concentration of alanine aminotranferase (ALAT) in a purified lyophilized material of porcine origin (heart) when measured by the IFCC recommended method at 37 degrees Celcius. The catalytic concentration of ALAT in reconstituted material is certified to 186 +/- 4 U/L or 3.09 +/- 0.07 Ákat/L. It is the intention that the reference material should be used to control and optimize the performance of enzyme measurements, verify the comparability of results from different laboratories and can be used as a reference material for manufacturers of reagents and diagnostic kits.

Additional information

Authors: CERIOTTI F ET AL, International Federation of Clinical Chemistry Laboratory Medicine, on behalf of the working group for calibrators in clinical enzymology;SIEKMANN L, Deusche Gesellschaft f³r Klinische Chemie e.V., Reference Institute of Bioanalysis, Bonn (DE);PAUWELS J, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE);SCHIMMEL H, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE);LINSINGER T, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE);KRISTIANSEN N, European Commission, Joint Research Centre, Institute for Reference Materials and Measurements, Geel (BE)
Bibliographic Reference: EUR 19579 EN (2000) 11 pp.
Availability: Available free of charge from Documentation Service JRC Ispra
Record Number: 200012238 / Last updated on: 2001-06-12
Category: PUBLICATION
Original language: en
Available languages: en
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