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FP5

ECVAM's in-house prevalidation / validation studies in the areas of haematotoxicity, reproductive toxicity, metabolism-mediated toxicity and epithelial barrier function.

Funded under: FP5

Abstract

The European Centre for the Validation of Alternative Methods (ECVAM) facilitates, co-ordinates and participates in validation activities at the European Union level. Various experimental studies, e.g. in the areas of haematotoxicity, reproductive toxicity, nephrotoxicity and epithelial barrier function, and metabolism-mediated toxicity, are underway in ECVAM's laboratories. ECVAM itself is currently involved in the prevalidation / validation of two assays, the colony-forming unit granulocyte / macrophage (CFU-GM) assays for predicting acute neutropenia and the embryonic stem cell test for predicting embryotoxicity. In the areas of metabolism-mediated toxicity and nephrotoxicity and epithelial barrier function, several assays are in the course of development. In many cases, the recommendations of various ECVAM workshops are being followed.

Additional information

Authors: PRIETO P, European Commission, Joint Research Centre, Institute for Health and Consumer Protection, Ispra (IT)
Bibliographic Reference: Article: The Science of the Total Environment, Vol. 247 (2000) pp. 349-354
Availability: The Science of the Total Environment (Journal)
Record Number: 200012762 / Last updated on: 2000-09-19
Category: PUBLICATION
Original language: en
Available languages: en
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