ECVAM's in-house prevalidation / validation studies in the areas of haematotoxicity, reproductive toxicity, metabolism-mediated toxicity and epithelial barrier function.Funded under: FP5
The European Centre for the Validation of Alternative Methods (ECVAM) facilitates, co-ordinates and participates in validation activities at the European Union level. Various experimental studies, e.g. in the areas of haematotoxicity, reproductive toxicity, nephrotoxicity and epithelial barrier function, and metabolism-mediated toxicity, are underway in ECVAM's laboratories. ECVAM itself is currently involved in the prevalidation / validation of two assays, the colony-forming unit granulocyte / macrophage (CFU-GM) assays for predicting acute neutropenia and the embryonic stem cell test for predicting embryotoxicity. In the areas of metabolism-mediated toxicity and nephrotoxicity and epithelial barrier function, several assays are in the course of development. In many cases, the recommendations of various ECVAM workshops are being followed.
Bibliographic Reference: Article: The Science of the Total Environment, Vol. 247 (2000) pp. 349-354
Availability: The Science of the Total Environment (Journal)
Record Number: 200012762 / Last updated on: 2000-09-19
Original language: en
Available languages: en