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The new version of ISO Guide 34 requires producers of certified reference materials (CRMs) to include contributions of possible instabilities in the overall CRM shelf life. This is done in order to obtain compliance with the Guide to the Expression of Uncertainty in Measurement (GUM).

In this report a, pragmatic approach to estimate the uncertainty of stability is presented. It relies on regression analysis of stability data with subsequent testing of the slope of the regression line for significance. If the slope is found statistically insignificant, a shelf life is chosen and the uncertainty connected to this time is estimated via the standard deviation of the slope. This uncertainty is included in the overall uncertainty of the CRM. This approach is explained with examples showing its applicability to matrix CRMs.

Additional information

Authors: LINSINGER ET AL, JRC, Institute for Reference Materials and Measurements, Geel (BE);VAN DER HEEN A, Nederlands Meetinstituut (NL);SEIKMANN L, Reference Institute for Bioanalysis, Bonn (DE)
Bibliographic Reference: Oral Report: 8th International Symposium on Biological and Enviromental Reference Materials, 17-22 September, 2000, Maryland (US)
Availability: 1 as paper EN 61334 ORA
Record Number: 200012848 / Last updated on: 2000-11-07
Original language: en
Available languages: en
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