Community Research and Development Information Service - CORDIS


EU legislation is regulating the use of a series of veterinary drugs for food producing animals. These pharmaceuticals are either completely banned or they must not exceed the Maximal Residue Limits (MRL) which are defined for a specific tissue or body fluid.

Demonstrated infractions have very heavy legal consequences. Against this background, it is understandable that both the consumer-whose protection from potentially dangerous residues in food is mainly taken care of by the respective national laboratory infrastructure -and the industry providing food of animal origin request highly reliable analytical results.

The EU RTD programme on "Standards, Measurements and Testing", which continues the preparation and certification of the BCR reference materials, is responding to this need. CRMs are the tool to provide the European laboratory infrastructure with a common level of analytical performance and to link their results to SI units.

This report describes the preparation and certification of reference material for Oxytetracycline in lyophilized bovine milk matrix: CRM 493, as analytical blank, stems from an untreated dairy cow and CRM 492 is an authentically incurred material, obtained from a dairy cow to which Oxytetracycline was administered by intramammary injection.

The homogeneity and the stability of the materials was demonstrated and the specific tests did not reveal any contradicting results. The methods of analysis used for the certification of the substance concentration of oxytetracycline in the reconstituted samples were all based on high performance liquid chromatography.

Additional information

Authors: MORETAIN J.P, CNEVA Laboratories des Medicaments Veterinaires Javene, Fougeres (FR);DIRSCHERL C, EC-Standards, Measurements and Testing Programme, Brussels (BE);HEITZMAN R.J, Compton, Berks (UK);CUNNINGHAM N.F, Ripley, Surrey (UK)
Bibliographic Reference: EUR 19621 EN (2000), 24pp, Euro: Free of charge
Availability: Available from European Commission, DG XII Communication Unit rue de la Loi/Wetstraat 200, B-1049 Bruxelles (BE) Tel: +32-2-2950001 Fax:+32-2-2958220 email:
ISBN: ISBN 92-828-9575-0
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