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  • Prospects in research on assessing the risk of exposure from low doses of metals in traces: the role of in vitro toxicity tests in integrated strategies

Abstract

In the last decades the quantitative differences between environmental and occupational exposure to trace metals are steadily decreasing, falling into the category of "chronic low-level exposure". Since there is evidence on relationships between low dose exposure to metals and certain diseases (e.g. neurological and cardiovascular disease, and infertility) the study of the toxic effects and mechanisms of toxicity induced by low-level metal exposure plays a key role in improving the scientific basis of risk assessment.

This work presents experimental results obtained by in vitro toxicity testing (screening tests and mechanistic studies) as well as human studies (establishment of reference valves of metals in indicator media) as example of contribution to an integrated toxicity profile regarding toxicological aspects, of low dose trace metal exposure in occupational medicine. The role of radioactive metal isotopes in overcoming the serious analytical obstacles in metabolic studies of low dose of metals in cell culture systems (Balb/3T3, PC12, HaCat cell lines as models of metal carcinogenicity, neurotoxicity and dermatotoxicity) is also showed.

Additional information

Authors: SABBIONI E, JRC-Institute for Health and Consumer Protection, EVCAM Unit (European Centre for the Validation of Alternative Methods), Ispra, Varese (IT);BALLS M, JRC-Institute for Health and Consumer Protection, EVCAM Unit (European Centre for the Validation of Alternative Methods), Ispra, Varese (IT);FORTANER S, JRC-Institute for Health and Consumer Protection, EVCAM Unit (European Centre for the Validation of Alternative Methods), Ispra, Varese (IT);PIETRA R, JRC-Institute for Health and Consumer Protection, EVCAM Unit (European Centre for the Validation of Alternative Methods), Ispra, Varese (IT);WORTH A, JRC-Institute for Health and Consumer Protection, EVCAM Unit (European Centre for the Validation of Alternative Methods), Ispra, Varese (IT)
Bibliographic Reference: 63 Congresso Nationale,Organiser: Societa Italiana di Medicina del Lavoro e Igiene Industriale, 8-11 November 2000
Record Number: 200013026 / Last updated on: 2001-01-30
Category: PUBLICATION
Original language: it
Available languages: it
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