Estimation of the uncertainty of CRMs in Accordance with GUM: Application to the certification of Four Enzyme CRMs
Uncertainties of four enzyme-CRMs that have recently been certified in a co-operation between the IRMM and the International Federation for Clinical Chemistry were estimated. Estimation was based on the sum of the uncertainties of characterisation, homogeneity and stability. Data from the certification collaborative study were used to estimate laboratory uncertainties, which form the basis for the uncertainty of characterisation. Estimations for the uncertainty of homogeneity were derived from classical homogeneity studies. The estimations of uncertainty of stability caused the most difficulties. Realistic uncertainties fitting the needs of customers while being derived from measurement data based on theoretical considerations were obtained.
Bibliographic Reference: Article published in: Fresenius' Journal of Analytical Chemistry (2000), pp 583-594
Record Number: 200013148 / Last updated on: 2001-03-20
Original language: en
Available languages: en