Community Research and Development Information Service - CORDIS

Abstract

Uncertainties of four enzyme-CRMs that have recently been certified in a co-operation between the IRMM and the International Federation for Clinical Chemistry were estimated. Estimation was based on the sum of the uncertainties of characterisation, homogeneity and stability. Data from the certification collaborative study were used to estimate laboratory uncertainties, which form the basis for the uncertainty of characterisation. Estimations for the uncertainty of homogeneity were derived from classical homogeneity studies. The estimations of uncertainty of stability caused the most difficulties. Realistic uncertainties fitting the needs of customers while being derived from measurement data based on theoretical considerations were obtained.

Additional information

Authors: LINSINGER T, JRC-Institute for Reference Materials and Measurements, Geel (BE);PAUWELS J, JRC-Institute for Reference Materials and Measurements, Geel (BE);SCHIMMEL H, JRC-Institute for Reference Materials and Measurements, Geel (BE);LAMBERTY A, JRC-Institute for Reference Materials and Measurements, Geel (BE);VAN DER VEEN A, Nederlands Meetinstituut (Nmi), (NL);SCHUMANN G, Medizinische Hochschule Hannover, Institut fur Klinische Chemie, (DE);SIEKMANN L, Institut fur Klinische Biochemie, University of Bonn, (DE)
Bibliographic Reference: Article published in: Fresenius' Journal of Analytical Chemistry (2000), pp 583-594
Record Number: 200013148 / Last updated on: 2001-03-20
Category: PUBLICATION
Original language: en
Available languages: en