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This study analyses the ability of four non-invasive techniques (laser Doppler velocimetry, evaporimetry, chromametry and corneometry) to discriminate between irritant and non-irritant products, when compared to appropriate controls, and to detect subliminal changes in barrier function and erythema. These changes, which remain undetectable in the traditional visual and palpable clinical assessment, can be used as early reactions that are followed by the development of overt skin irritation.

Additional information

Authors: ZUANG V, JRC-Institite for Health and Consumer Protection, Ispra (IT);ARCHER G, JRC-Institite for Health and Consumer Protection, Ispra (IT);RONA C, Policlinico San Matteo, Pavia (IT);BARARDESCA E, Policlinico San Matteo, Pavia (IT)
Bibliographic Reference: Article published in: Skin Pharmacology and Applied Skin Physiology 2000, 13, pp358-371
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