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  • Differences in trace element concentrations between alzheimer and normal human brain tissue using Instrumentsl Neutron Activation Analysis (INAA)


Brain samples obtained from the Netherlands Brain Bank were taken from the superior frontal gyrus, superior parietal gyrus and medial temporalis gyrus of 'normal' and Alzheimer's Disease subjects in order to determine elemental concentrations and compare elemental composition.

Brain samples from the cortex were taken from 18 subjects, eight 'normal' (6 males and 2 females) and eleven with Alzheimer's disease, (1 male and 10 females) and the following elemental concentrations, Na, K, Fe, Zn, Se, Br, Rb, Ag, Cs, Ba, and Eu were determined by Instrumental Neutron Activation Analysis (INAA).

The element which showed the greatest difference in all areas was Br which was found to be significantly elevated in the Alzheimer's Disease brains as compared to the 'normal'.

Additional information

Authors: PART P, Environmental Impact, JRC, Ispra (IT);SPYROU N.M, Physics Department, University of Surrey, Guildford, Surrey (UK);PANAYI A.E, Physics Department, University of Surrey, Guildford, Surrey (UK)
Bibliographic Reference: An oral report given at: MARC5 Conference. Organised by: Professor Filby, Department of Chemistry, University of Washington, (US). Held in: Hawaii 10-14 April, 2000
Record Number: 200013259 / Last updated on: 2001-05-15
Original language: en
Available languages: en
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