Community Research and Development Information Service - CORDIS


A new ethical scheme is proposed for evaluating the ethical acceptability of research work involving animal experimentation, including transgenic animals, in the biomedical sciences and at the European level. The scheme falls within the scope of Recommendation 1 of the ECVAM workshop on The Use of Transgenic Animals in the European Union (EU), concerning the need to develop regulatory tools to provide for the harmonised and rationalised control of the use of transgenic animals throughout the EU, since current legislation on animal experimentation, such as Directive 86/609/EEC, does not specifically cover such animals. In addition, the scheme builds on Recommendation 4 of the ECVAM workshop, concerning the need for a broad and systematic ethical assessment of all proposals for work involving transgenic animals. An analysis of selected existing cost-benefit guidelines showed that these do not provide for an adequate evaluation of the ethical issues raised by animal transgenesis. Such issues, involving specific considerations related to animal welfare requirements, relevant applications of the Three Rs concept, intrinsic ethical concerns relating to the transfer of genes between species, and the wider societal and environmental implications of the technology and its current, or potential, applications, have been subjected to close scrutiny in the proposed scheme.

Additional information

Authors: DELPIRE V, Institute for Health and Consumer Protection, Ispra (IT);BALL M, Institute for Health and Consumer Protection, Ispra (IT);MEPHAM B, University of Nottingham (UK)
Bibliographic Reference: An oral report given at: Third World Congress on Alternative and Animal Use in the Life Sceinces. Organised by: European Centre for the Validation of Alternative Methods. Held on: 29 August � 2 September 1999 Published for the proceed
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